Mechanism of Action

CINQAIR inhibits IL-5 signaling, thereby reducing the production and survival of eosinophils1-5*

Role of IL-5 in eosinophilic asthma


*The mechanism of action of CINQAIR in asthma has not been definitively established.

Teva Support Solutions®

REFERENCES: 1. CINQAIR Prescribing Information. West Chester, PA. Teva Respiratory, LLC. 2. Hogan SP, Mould AW, Young JM, et al. Cellular and molecular regulation of eosinophil trafficking to the lung. Immunol Cell Biol. 1998;76(5):454-460. 3. Rothenberg ME, Hogan SP. The eosinophil. Annu Rev Immunol. 2006;24:147-174. 4. Busse WW, Lemanske RF. Asthma. N Engl J Med. 2001;344(5):350-362. 5. Mould AW, Ramsay A J, Matthaei KI, Young IG, Rothenberg ME, Foster PS. The effect of IL-5 and eotaxin expression in the lung on eosinophil trafficking and degranulation and the induction of bronchial hyperreactivity. J Immunol. 2000;164(4):2142-2150.